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Product Information

For the treatment of adult,immature and early immature stages of liver fluke susceptible to triclabendazole in cattle and sheep.


  • Triclabendazole-based fluke treatment
  • Kills early immature, immature, and adult liver fluke
  • Complete chronic and acute fluke control in both cattle and sheep
  • Low volume dose helps ensure accurate dosing of stock
  • Approved for use on dairy cattle

Withdrawal Periods:

Meat and Offal:

Cattle: 56 days 

Sheep: 56 days


Endofluke 100 mg/ml is given as an oral drench and is suitable for most types of automatic drenching guns. The recommended dose rate is 12mg triclabendazole per kg body weight in cattle and 10mg triclabendazole per kg body weight in sheep.

To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked. If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.The timing for re-treatment should be based on epidemiological risk patterns and should be customised for each individual farm. To avoid the potential for the accumulation of residues following repeat administration of the product; animals should not be treated with a frequency of less than 10 weeks.

Practical Dosage Guide: CATTLE     6 ml per 50kg body weight

Animal Weight         Dose of product

50kg                           6ml

100kg                         12ml

150kg                         18ml

200kg                         24ml

250kg                        30ml

300kg                        36ml

350kg                        42ml

400kg                        48ml

For each additional 50kg 6ml

Practical Dosage Guide: SHEEP  1 ml per 10kg body weight

Animal Weight         Dose of product

10kg                           1ml

20kg                           2ml

30kg                           3ml

40kg                           4ml

50kg                           5ml

60kg                          6ml

For each additional 10kg 1ml

Withdrawal Period:

Cattle: Milk for human consumption may only be taken from 48 hours after calving.

Not intended for use within 45 days of calving. Should a cow calve earlier than 45 days after the last treatment, milk for human consumption may only be taken from 45

days + 48 hours (47 days) after the last treatment.

Sheep: Not authorised for use in ewes producing milk for human consumption, including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Special Warnings for Each Target Species:

Care should be taken to avoid the following practices, because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

  • Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
  • Under-dosing, which may be due to underestimation of body weight, misadministration of the product or lack of calibration of the dosing device.
  • Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
  • Resistance to triclabendazole has been reported in Fasciola hepatica in cattle and sheep.Therefore, the use of this product should be based on local (regional/farm) epidemiological information about susceptibility of the Fasciola hepatica and recommendations on how to limit further selection for resistance to anthelmintics.
Animal: Cattle, Sheep
Application Method: Drench

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